2-Bedroom Apartments for Rent in South San Francisco Under $4,000
South San Francisco is the Industrial City — biotech HQs (Genentech, and many others), the 'South San Francisco The Industrial City' hillside sign, and a South SF BART station plus Caltrain and SamTrans. More affordable than SF proper; commuter-heavy.
27 listings available — updated June 3, 2026, refreshed every 3 hours
21 Lewis Ave, 21 Lewis Ave APT 8, South San Francisco, CA 94080
$3,195/mo
15 Lewis Ave, 15 Lewis Ave Unit C, South San Francisco, CA 94080
$3,395/mo
Fernmar North, 208 Holly Ave #D, South San Francisco, CA 94080
$2,800/mo
Stop messaging landlords one by one
Sign up for free to see full details and we'll automatically reach out to landlords on your behalf. No payment info required.
Frequently asked
How many 2-bedroom apartments are available in South San Francisco right now?
As of June 3, 2026, Rentomatics tracks 27 2-bedroom apartments for rent in South San Francisco under $4,000/month. Listings refresh every 3 hours from Craigslist, Zumper, and other Bay Area sources.
What is the rent for a 2-bedroom in South San Francisco?
Among current Rentomatics listings, 2-bedroom apartments in South San Francisco start at $2,400/month, with an average of $3,288 and a median of $3,395/month. Prices reflect 27 active listings updated June 3, 2026.
How often are Rentomatics listings updated?
Rentomatics refreshes listings every 3 hours from Craigslist, Zumper, and other Bay Area rental sources. Stale listings are removed within 5 days of last sighting.
Does Rentomatics show broker fees?
Yes. Every Rentomatics listing displays whether a broker fee applies, and users can filter to show only no-fee apartments.
What is South San Francisco like?
South San Francisco is the Industrial City — biotech HQs (Genentech, and many others), the 'South San Francisco The Industrial City' hillside sign, and a South SF BART station plus Caltrain and SamTrans. More affordable than SF proper; commuter-heavy.